Researchers apply CRISPR technology to eliminate fusion genes present in tumor cells

The CRISPR/Cas9 gene-editing tool is one of the most promising approaches to advancing treatments of genetic diseases – including cancer -, an area of research where progress is constantly being made.

Now, the Molecular Cytogenetics Unit led by Sandra Rodríguez-Perales at the Spanish National Cancer Research Centre (CNIO) has taken a step forward by effectively applying this technology to eliminate so-called fusion genes, which in the future could open the door to the development of cancer therapies that specifically destroy tumors without affecting healthy cells. The paper is published in Nature Communications.

Fusion genes are the abnormal result of an incorrect joining of DNA fragments that come from two different genes, an event that occurs by accident during the process of cell division. If the cell cannot benefit from this error, it will die and the fusion genes will be eliminated.

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Microsoft digs at Apple with 10 principles for app store fairness, but they won’t apply to Xbox

Microsoft published and committed to following a list of 10 principles in its treatment of third-party apps on Windows, capitalizing on the ongoing backlash against Apple over the iPhone maker’s revenue sharing policies and restrictions on cloud streaming services in the iOS App Store.

The commitments include giving developers “the freedom to choose whether to distribute their apps for Windows through our app store,” and promising to allow competing app stores on Windows. In addition, Microsoft said in the post that it “will not block an app from Windows based on a developer’s business model or how it delivers content and services, including whether content is installed on a device or streamed from the cloud.”

The principles, published Thursday morning by Rima Alaily, Microsoft deputy general counsel, largely restate Microsoft’s existing practices. The company says it’s building on the ideas of the Coalition for App Fairness, which includes Epic Games,

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