Direct coupling of aryl halides and alkyllithium compounds by palladium catalysis — ScienceDaily

Palladium catalysts help synthesize key chemicals for many industries. However, direct reaction of two basic reagents, aryl halides and alkyllithium compounds, remains a challenge. Now, a team of scientists have found that a catalyst containing YPhos-type ligands can mediate this reaction even at room temperature. This discovery may contribute to the development of more sustainable processes in the chemical industry, the authors write in the journal Angewandte Chemie.

Palladium-catalyzed chemical processes are very useful. Palladium catalysts help to couple simple carbon-containing compounds to form more complicated chemical structures. However, they have yet failed to couple two common reagents in chemical synthesis, aryl halides and alkyllithium compounds. Among the aryl halides, aryl chlorides are common synthesis reagents that react variably during palladium-catalyzed reactions to produce side products.

For coupling reactions with aryl halides and alkyllithium compounds, chemists usually take “detours” by adding intermediate synthesis steps. Unfortunately, every extra synthesis step

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