New research is revealing how genetic differences in the fat in men’s and women’s bodies affect the diseases each sex is likely to get.
University of Virginia researchers Mete Civelek, PhD, Warren Anderson, PhD, and their collaborators have determined that differences in fat storage and formation in men and women strongly affect the activity of 162 different genes found in fat tissue. Further, 13 of the genes come in variants that have different effects in men and women.
Some of those genes identified have already been connected with conditions such as type 2 diabetes and cardiovascular disease. The findings help explain the differing health risks men and women face, and they set the stage for better, more targeted treatments.
“Obesity is associated with a number of health risks, and how men and women store excess calories as fat makes a difference in how they have different susceptibilities to common diseases,”