Patients who suffer an intracerebral hemorrhage (ICH) face an increased risk of acute kidney injury (AKI) during their hospitalization. AKI can lead to sudden kidney failure, kidney damage or even death. Researchers from the University of Missouri School of Medicine and MU Health Care have determined which ICH patients are at the highest risk for this kidney injury so doctors can take precautions to prevent it. They also examined how the commonly-used blood pressure lowering drug nicardipine contributes to AKI.
“Over the past five years, clinicians have been concerned about AKI as they see patients who present with ICH, then develop kidney failure and require dialysis,” said lead researcher Adnan I. Qureshi, MD, a professor of clinical neurology at the MU School of Medicine. “What we need is a more global body approach to improve the outcome of patients with ICH, rather than just focusing on the brain.”
Kidney injury is a dreaded complication in patients hospitalized for COVID-19, with more than a third of patients ending up in need of dialysis. Patients with COVID-19-related kidney injury are also at much higher risk of death.
“We don’t known exactly why patients with severe COVID-19 have a high rate of kidney injury,” says Salim Hayek, M.D., a cardiologist at the Michigan Medicine (University of Michigan) Frankel Cardiovascular Center and senior author of a new observational study.” It is, however, becoming clearer that a hyperactive immune system plays a major role in the morbidity of COVID-19, including kidney-related complications.”
In the multi-center study published in the Journal of the American Society of Nephrology, Hayek and an international team of experts report that levels of a protein in blood produced by immune cells and known to be involved in causing kidney disease are very high in patients hospitalized for COVID-19