The making of memory B cells and long-term immune responses

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IMAGE: B cell differentiation in GC
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Credit: Osaka University

Osaka, Japan — The current COVID-19 climate has made vaccines, antibodies, and immune responses topics of everyday conversation. Now, it isn’t just immunologists who want to know how our bodies respond to re-infections months, years, or sometimes decades after an initial immune response. A new study by Tomohiro Kurosaki at Osaka University shows that this ability requires Bach2, a protein that regulates the expression of genes needed to instruct activated B cells under selection to become memory B cells.

Like most biological processes, immune responses are complicated. They involve numerous types of cells and proteins, performing precise step-by-step processes. And of course, we don’t know all of them yet. For example, memory B cells are a type of white blood cell that are created in lymph nodes or spleens during an infection. They stick around for years and allow

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Death of the HQ? Pandemic hits commercial real estate, but long-term trends still open to debate

A rendering of one of Amazon’s new buildings in Bellevue, Wash. (Vulcan Image)

“HQ’s are finished.”

That was the hot take this week from Chris Herd, founder and CEO of remote work setup startup Firstbase. After speaking with about 1,000 companies over the past six months, he estimates that many will be cutting their office space by as much as 40% to 60%. About 90% of workforces indicated that they “never want to be in an office again full-time,” he wrote.

The latest example of the trend is the news this morning that working from home will be a permanent part of the mix at Microsoft. Boosting access to talent, reducing costs, and quality of life were among the benefits of remote work cited by companies in Herd’s informal survey.

“Good thread on the future of work. I agree with him,” former Zillow Group CEO Spencer Rascoff chimed in

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Lab develops unprecedented long-term wildfire prediction model

Argonne develops unprecedented long-term wildfire prediction model
Wildfires burn across the West, affecting California, Oregon and Washington. Credit: Shutterstock / My Photo Buddy

Wildfire indices and high-resolution climate models combine to produce a detailed historical analysis of wildfire events across the U.S. and suggest the potential for more severe and frequent fires in the latter half of the century.


The list is long, some of the names familiar: Sunflower, Paradise, Whitewater-Baldy, Apple, Pinecreek. Names that invoke images of pastoral respites away from the busy world.

Now those names are synonymous with wildfires.

The number and severity of wildfires are making headlines across the globe, from the Western United States to Brazil, from Siberia to Australia. Wildfires devastate the environment, decimating huge swaths of land and wildlife populations—it is estimated, for example, that a half billion animals perished in the megafires that recently swept Australia. Beyond their impact on nature, wildfires also take a toll on air quality,

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In study, 15 patients with long-term PD and chronic pain and mobility impairment showed improvements across multiple measures — ScienceDaily

A team of researchers in the United States and Japan reports that spinal cord stimulation (SCS) measurably decreased pain and reduced motor symptoms of Parkinson’s disease, both as a singular therapy and as a “salvage therapy” after deep brain stimulation (DBS) therapies were ineffective.

Writing in the September 28, 2020 issue of Bioelectronic Medicine, first author Krishnan Chakravarthy, MD, PhD, assistant professor of anesthesiology at University of California San Diego School of Medicine, and colleagues recruited 15 patients with Parkinson’s disease, a neurodegenerative disorder that is commonly characterized by physical symptoms, such as tremors and progressive difficulty walking and talking, and non-motor symptoms, such as pain and mental or behavioral changes.

The mean age of the patients was 74, with an average disease duration of 17 years. All of the patients were experiencing pain not alleviated by previous treatments. Eight had undergone earlier DBS, a non-invasive, pain therapy in

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Global ADAS & Autonomous Driving Technology Market Report 2020: Covid-19 Impact Analysis & Long-term Forecast to 2040

DUBLIN–(BUSINESS WIRE)–Sep 30, 2020–

The “Edition 2020, ADAS & Autonomous Driving Technology – Market & Industry Analysis, Forecast – 2020 – 2040” report has been added to ResearchAndMarkets.com’s offering.

By the end of 2020, the global passenger vehicle demand is predicted to plunge by 11% due to Covid-19 pandemic and commercial vehicle industry is expected to witness a fall in the demand for the first time in the decade

All the major markets are estimated to witness sharp decline, while, the countries including the U.S., Italy, India, France, South Korea, Japan, China, United Kingdom, and Spain are expected to witness fall of more than 10%. From a more optimistic perspective, the year 2021 could see a positive growth- curve in terms of passenger cars demand; however, the auto industry would at least need minimum of 5 years’ time to regain the sales volumes of 2019.

The publisher predicts that passenger

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long-term effects on tundra vegetation — ScienceDaily

Landslides have long-term effects on tundra vegetation, a new study shows. Conducting the study in North West Siberia, the researchers found that tundra vegetation regenerated rapidly after a major landslide event in 1989. Two decades later, differences in the vegetation of the landslide area and the areas surrounding it have evened out, but even after 30 years, the vegetation of the landslide area is nowhere close to the vegetation of the surrounding areas.

Several studies have reported changes in the Normalized Difference Vegetation Index (NDVI) in Arctic regions. So far, remote sensing data that is used to calculate the NDVI hasn’t been able to discern, in detail, landscape level factors that have an effect on, e.g., greening.

“Landslides caused by the thawing of permafrost will become increasingly common in North West Siberia and elsewhere in the Arctic, too. These are caused by climate change and they also have an effect

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Flutter Entertainment and Scientific Games Celebrate 20 Year Global Sports Betting Partnership with Long-Term Renewal

Scientific Games fueling sport betting growth for FanDuel, Betfair, Paddy Power, Sky Betting and Gaming and Sportsbet

LAS VEGAS, Sept. 28, 2020 /PRNewswire/ — Scientific Games Corporation (NASDAQ: SGMS) (“Scientific Games” or the “Company”) secured a five-year contract renewal with long-term customer Flutter Entertainment plc to continue providing its OpenSports™ technology to the operators’ portfolio of global brands.

Scientific Games Corporation
Scientific Games Corporation

Flutter Entertainment is the world’s leading sports betting, gaming and entertainment provider serving over 13 million customers worldwide through its innovative, diverse and distinctive brands including FanDuel in the U.S., Paddy Power, Betfair and Sky Bet in the U.K. and Europe and SportsBet in Australia.

The five-year renewal comes on the back of FanDuel selecting Scientific Games to power their sportsbook offering across all current and future regulated markets in the U.S.

Flutter Entertainment and Scientific Games first partnered with Paddy Power in 2000 making

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Keys to controlling a COVID-19 outbreak in a long-term care facility — ScienceDaily

Widespread COVID-19 testing may be an obvious way to control an outbreak in a long-term care facility. But communication among the facility’s staff, its residents and the residents’ family members is crucial, too.

A new study led by Carl Shrader, a physician and researcher in the Department of Family Medicine in the West Virginia University School of Medicine, revealed the role that communication played in quashing a COVID-19 outbreak at Sundale, a long-term care facility in Morgantown.

“Timely communication was challenging and made more difficult by a lack of evidence-based information and widely circulating misinformation,” said Shrader, who directs WVU’s residency program. “There is a delicate balance between rapid dissemination of accurate information with the need for personal individual discussion in an unknown situation.”

Shrader is also the medical director at Sundale, which was the epicenter of West Virginia’s COVID-19 pandemic. From the first diagnosis of COVID-19 in a Sundale

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A long-term battle: The tech industry’s role in combatting climate change

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Image: Intel

As the world continues to make attempts at urgently containing the COVID-19 pandemic, there is an even more dire issue that needs to be addressed: Climate change.

New research, published in last month’s edition of the journal Communications Earth and Environment, found that in 2019, Greenland’s ice sheet lost an annual record of 532 billion tonnes of ice. For perspective, between 2003 and 2016, Greenland’s ice sheet lost on average about 255 billion tonnes of ice each year.

Further evidence of climate change worsening was seen last week when a large chunk of Greenland’s ice cap, estimated to be 110 square kilometres in size, broke off in the far north-east Arctic, the Associated Press reported.

But climate change is no longer a conversation only had among environmental activists. Technology companies and their leaders are getting involved too, with many joining the fight.

This year alone there have

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Windstream Secures Future for Long-Term Growth and Technology Leadership

Reduced Debt by More Than $4 Billion and Has Access to Approximately $2 Billion in New Capital to Fuel Sustainable Growth and Value Creation

Windstream Holdings, a communications and software company, today announced that the company has successfully completed its financial restructuring process as a privately held company. Through this process, the company has reduced its debt by more than $4 billion, or approximately two-thirds, and now has access to approximately $2 billion in new capital. With an enhanced capital structure, Windstream is now well-positioned to continue making substantial network and software investments, fuel sustainable growth and drive value for all its stakeholders.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200921005889/en/

Windstream President & CEO Tony Thomas (Photo Credit: Karen E. Segrave)

“Today marks the start of a new era for Windstream as an even stronger, more competitive company,” said Tony Thomas, president and chief executive officer

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