What can we learn from mathematical modeling

Human heart in space: What can we learn from mathematical modeling
Examples of pressures (P) and flow rates (Q) throughout the human body: on Earth (blue) and spaceflight (red) configurations. Credit: Politecnico di Torino

Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology and push scientific boundaries further. A key aspect of long-term human spaceflight is the physiological response and consequent microgravity (0G) adaptation, which has all the features of accelerated aging involving almost every body system: muscle atrophy and bone loss, onset of balance and coordination problems, loss of functional capacity of the cardiovascular system.


Research published recently in npj Microgravity and conducted by Caterina Gallo, Luca Ridolfi and Stefania Scarsoglio shows that human spaceflight reduces exercise tolerance and ages astronauts’ heart.

The study is based on a mathematical model which allowed to investigate some spaceflight mechanisms inducing cardiovascular deconditioning, that is the adaptation of the cardiovascular system

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