Multiple neurodevelopmental conditions may lead to worse educational outcomes — ScienceDaily

Scottish children with multiple neurodevelopmental conditions experience greater school absenteeism and exclusion, poorer exam attainment and increased unemployment, according to a study published October 13 in the open-access journal PLOS Medicine by Michael Fleming of the University of Glasgow, and colleagues.

Children with neurodevelopmental conditions such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), depression and intellectual disability often experience difficulties at school. Multiple neurodevelopmental conditions commonly coexist, but this phenomenon, known as neurodevelopmental multimorbidity, has received relatively little attention in children compared to adults. To address this gap in knowledge, Fleming and his collaborators investigated the prevalence of neurodevelopmental multimorbidity in Scottish schoolchildren and their educational outcomes compared to their peers. The authors linked together five Scotland-wide health and education databases to identify neurodevelopmental multimorbidity in 766,244, four- to 19-year-old children attending school in Scotland between 2009 and 2013. Study limitations are that 96.2% of the participants

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Cryoport: A Levered Refrigerator Manufacturer Trading At A Tech Multiple, $10 Price Target (NASDAQ:CYRX)

I have written on Cryoport (NASDAQ:CYRX) before, highlighting the total lack of a moat in the base business. Since that report the company has made two acquisitions, in competitive deals, that show the multiple is massively out of whack with what other buyers are willing to pay. In addition the sell side has run the stock up on the theory that CYRX will be a beneficiary of the COVID 19 vaccine distribution effort. This narrative is without merit, Pfizer (PFE) and the CDC have completely discredited the Sellside analysts interpretation here.

Below I will highlight that CYRX has morphed from an oddball ultra cold storage shipping service into a leveraged appliance manufacturer. The upside risk of vaccine distribution is extremely low, and that the likely outcome is that shareholders wake up next year with the realization that they own an appliance company trading at ~92x EBITDA. The downside scenario is

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Simple sugar possible therapy for repairing myelin in multiple sclerosis — ScienceDaily

N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study.

Published in the Journal of Biological Chemistry, the study also demonstrates that in mice, delivering N-acetylglucosamine orally to lactating mothers drove primary myelination in their nursing offspring. N-acetylglucosamine is a simple sugar that is metabolically attached to proteins at the cell surface to control cellular function.

“We found that N-acetylglucosamine activates myelin stem cells to promote primary myelination and myelin repair,” said Michael Demetriou, MD, PhD, FRCP(C), professor of neurology, microbiology and molecular genetics at UCI School of Medicine and leader of the study. “Our data raises the intriguing possibility that N-acetylglucosamine may be a simple therapy to promote myelin repair in multiple sclerosis patients.”

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In study, 15 patients with long-term PD and chronic pain and mobility impairment showed improvements across multiple measures — ScienceDaily

A team of researchers in the United States and Japan reports that spinal cord stimulation (SCS) measurably decreased pain and reduced motor symptoms of Parkinson’s disease, both as a singular therapy and as a “salvage therapy” after deep brain stimulation (DBS) therapies were ineffective.

Writing in the September 28, 2020 issue of Bioelectronic Medicine, first author Krishnan Chakravarthy, MD, PhD, assistant professor of anesthesiology at University of California San Diego School of Medicine, and colleagues recruited 15 patients with Parkinson’s disease, a neurodegenerative disorder that is commonly characterized by physical symptoms, such as tremors and progressive difficulty walking and talking, and non-motor symptoms, such as pain and mental or behavioral changes.

The mean age of the patients was 74, with an average disease duration of 17 years. All of the patients were experiencing pain not alleviated by previous treatments. Eight had undergone earlier DBS, a non-invasive, pain therapy in

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Scientists find evidence of multiple underground lakes on Mars

Scientists believe they’ve found more evidence confirming the presence of a large reservoir of liquid water under the surface of Mars first discovered back in 2018. In fact, they believe they’ve found three more subsurface saltwater lakes surrounding that main one — a huge discovery, seeing as those lakes are potential habitats for life. As Nature notes in its post about the scientists’ paper, the first finding was met with lot of skepticism because it was only based on 29 observations from 2012 to 2015. This study and its findings were based on 134 observations made between 2012 and 2019.



Mars


Mars

The team used data from a radar instrument on the European Space Agency’s (ESA) Mars Express spacecraft to investigate the planet’s southern polar region. Mars Advanced Radar for Subsurface and Ionosphere Sounding or MARSIS, as the instrument is called, is capable of sending out radio waves that bounce off

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Could Life Exist On Mars? Scientists Discover Multiple Underground Salty Ponds

KEY POINTS

  • Researchers say they have discovered a group of lakes hidden under Mars’ icy surface
  • This follows the detection of another subsurface lake in the same region in 2018
  • The findings revived the debate on whether the Red Planet has alien life or can house microorganisms

A team of Italian scientists discovered a group of three salty ponds beneath Mars’ south pole. The findings revived the debate on whether the Red Planet has alien life or at least can house microorganisms. 

The discovery of these ponds raised the possibility that microbial organisms could survive on Mars but the only hindrance was the high amount of salt concentration, which could be keeping the waters frozen, scientists said in a report published on Sept. 28 in Nature Astronomy.   

The discovery of the salty ponds was significant because their locations were close to another lake discovered in 2018. The largest of them

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Microsoft 365 Outage Affects Multiple Services | Top News

(Reuters) – Microsoft Corp

said late Monday a recent change it introduced likely caused a major outage, affecting users’ access to multiple Microsoft 365 services, including Outlook.com and Microsoft Teams.

The developer of Windows and Office software said it did not “observe an increase in successful connections” even after it rolled back the change to mitigate the impact.

“A moment ago nothing was working, then I went into files in Teams and it was working, now nothing is working. Well I guess now I have an excuse to not do work and watch TV,” one Twitter user tweeted.

“We’re pursuing mitigation steps for this issue. In parallel, we’re rerouting traffic to alternate systems to provide further relief to the affected users,” Microsoft said on its status page, without specifying how many users were affected.

Several other Twitter users complained that the outage meant they could miss their job interviews and

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AB Science Presents Phase 2B/3 Study Results in Progressive Multiple Sclerosis at the World’s Largest Multiple Sclerosis Research Conference

The MarketWatch News Department was not involved in the creation of this content.

AB Science Presents Phase 2B/3 Study Results in Progressive Multiple Sclerosis at the World’s Largest Multiple Sclerosis Research Conference

  • 50% of patients suffering from multiple sclerosis have one of the progressive forms of the disease, for which there is no satisfactory treatment to date
  • Masitinib, a tyrosine kinase inhibitor developed by AB Science, provides the first clinical evidence that targeting the innate immune system is an effective strategy for the treatment of progressive forms of multiple sclerosis.

AB Science SA (Euronext – FR0010557264 – AB), a pharmaceutical company specialized on the research, development and commercialization of protein kinase inhibitors (PKIs), announced today that it has presented the world’s first key results from its Phase 2B/3 study (AB07002) evaluating its lead product, masitinib, in both progressive forms of multiple sclerosis1 during the 8th Joint Meeting of

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Source Code For Multiple Windows Operating Systems Publicly Leaks

Microsoft has had to contend with quite a number of major leaks over the last few years, including everything from parts of the Windows 10 source code in 2017 to a Bing app server that recently leaked multiple terabytes of GPS data and user searches for more than week. On top of all that, it appears that a ~43GB archive of Microsoft source code, including the Windows XP (with Service Pack 1) and Windows Server 2003 operating systems, has reportedly leaked, along with a array of older OSes, including a few versions of Windows CE and MS-DOS.

Both Windows XP SP1 and Windows Server 2003 have been EOL for quite some time now. Current estimates put Windows XP’s market share at about 1.26% (and falling). Windows Server 2003’s share among connected servers is even lower and is estimated to be approximately .57% as of today. The

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A woman who says she broke multiple bones when she crashed an Uber scooter is suing the firm for failing to fit turn signals



a car parked on a city street: Irene Jiang / Business Insider


© Irene Jiang / Business Insider
Irene Jiang / Business Insider

  • A woman in Colorado is suing Uber for failing to equip rental scooters with turn signals after she allegedly crashed a Jump scooter in 2019, ending up with a dislocated hip and multiple fractures.
  • Her injuries have resulted in hours of surgery, according to the lawsuit she filed against the vehicle and delivery service giant.
  • Erin Norman, who says she crashed on a street in San Francisco in 2019, is accusing Uber of not fitting the Jump scooters with turn signals, despite designing them for use in cities.
  • Other defendants in the case are Neutron Holdings, which operates as Lime and acquired Jump in May, and manufacturers Segway and Xiaomi.
  • Visit Business Insider’s homepage for more stories.

A woman who says she dislocated her hip and broke multiple bones when she crashed an Uber rental scooter is suing the

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