EXCEL, SYNTAXES Analyses Spotlight Periprocedural MI Controversy

Investigators from the EXCEL trial have doubled down on the July publication of their study’s outcomes based on an alternative definition of myocardial infarction (MI) resulting from coronary revascularization, a key part of the controversy that has dogged EXCEL for a year or more.

The latest, more granular EXCEL analysis pits periprocedural MI (PMI), as defined in the trial’s protocol, against PMI according to the more stringent third Universal Definition Of Myocardial Infarction (UDMI). The stakes for EXCEL’s message are high because PMI is part of the composite primary end point.

The new analysis concludes with a preference for interpreting EXCEL — which compared percutaneous coronary revascularization (PCI) and coronary artery bypass (CABG) surgery in patients with left-main coronary artery disease (LMCAD) — using the protocol-specified PMI definition, which was based solely on levels of CK-MB (and sometimes troponin), rather than the UDMI. That alternative definition adds clinical signs, electrocardiography

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New smartphone app analyses coronavirus genome in minutes

Melbourne, Sep 29 (PTI) Scientists have developed a new smartphone app that can analyse the genome of the SARS-CoV-2 virus, that causes COVID-19, within minutes.

Described in the journal Communications Biology, the ‘Genopo’ app makes genetic material more accessible to remote or under-resourced regions, as well as the hospital bedside.

‘Not everyone has access to the high-power computing resources that are required for DNA and RNA analysis, but most people have access to a smartphone,’ said Ira Deveson from the Garvan Institute of Medical Research in Australia.

‘Fast, real-time genomic analysis is more crucial today than ever, as a central method for tracking the spread of coronavirus. Our app makes genomic analysis more accessible, literally placing the technology into the pockets of scientists around the world,’ Deveson said.

The researchers tested Genopo on the raw sequencing data of virus samples isolated from nine Sydney patients infected with SARS-CoV-2.

They extracted

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