Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug. This mitochondrial-targeted prodrug — an inactive compound that cancer cells selectively metabolize to produce an active toxic drug — also greatly improves outcomes when coupled with standard therapies of radiation and/or chemotherapy. The drug selectively targets and destroys the DNA inside the glioblastoma cell mitochondria (the energy factory of the cancer cell) leaving normal cells intact.
In an Oct. 8 study published online in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, investigators used a second generation prodrug called MP-Pt(IV) to target the deadly cells of glioblastoma tumors, a brain cancer that is almost always fatal and has no cure. Life expectancy in humans with glioblastoma ranges from a few months to two years.
“We practice in the rain all the time,” Gibbs said. “When it rains we just keep practicing outside to get used to it.”
Georgia Tech (2-2, 2-1 Atlantic Coast Conference) snapped a two-game losing streak. Sims, a freshman, passed for 249 yards with two touchdowns, including a 34-yard scoring pass to Malachi Carter to extend the lead with less than three minutes remaining. Dontae Smith added a 12-yard scoring run in the final minute.
Louisville (1-3, 0-3) suffered its third straight loss despite a strong effort by quarterback Malik Cunningham, who passed for 229 yards with two touchdowns and ran for two scores.
Javian Hawkins ran for 155 yards for the Cardinals but his fumble in the fourth quarter was costly. Jordan Domineck’s recovery near midfield set up Sims’ scoring pass to Gibbs, who vaulted defensive back Isaiah Hayes at the goal line
Valassis, a Vericast business and the leader in marketing technology and consumer engagement, is defining and creating industry benchmarks with its newly introduced influencer marketing solution. Valassis influencer marketing programs drove a 64% higher engagement rate for awareness campaigns and 110% higher click-through rate for traffic campaigns based on 32 consumer packaged goods brands testing nearly 3,000 pieces of content.
“Consumers want to interact with brands in a more experiential way, relying in part, on influencers for brand discovery and digital storytelling,” said Sinead Norenius-Raniere, vice president of influencer marketing and paid social at Valassis. “Effective influencer marketing is both an art and a science, strategically identifying the right influencers, message and channels to reach a receptive audience, and ultimately, inspire purchase decisions. At Valassis, we are able to buy and serve media programmatically via our influencers’ handles, providing brands incredible efficiencies and maximizing their investments. We are also setting
Campaigns and elections have always been about data—underneath the empathetic promises to fix your problems and fight for your family, it’s a business of metrics. If a campaign is lucky, it will find its way through a wilderness of polling, voter attributes, demographics, turnout, impressions, gerrymandering, and ad buys to connect with voters in a way that moves or even inspires them. Obama, MAGA, AOC—all have had some of that special sauce. Still, campaigns that collect and use the numbers best win.
That’s been true for some time, of course. In 2017, Hillary Clinton lamented that the Democratic National Committee had supplied her team with out-of-date data. She blamed this in part for her loss to Donald Trump, whose campaign sat atop an impressive Republican data-crunching machine. (The DNC retorted that it wasn’t the data, but how it was used, that was inadequate.)
The European Union is seeking new powers to police and penalize technology giants, like Apple, if their market dominance appears to threaten consumers or smaller rivals.
In recent years, the EU has stepped up efforts to curb the power of tech giants. In July, the EU announced plans to impose new tax, privacy, and online content rules.
Now, Brussels is seeking new powers to take on tech giants, including the ability to compel tech giants to break up, sell their European operations, or exclude companies from a single market altogether, The Financial Times reported on Monday.
Additionally, the EU is also mulling a rating system that could allow stakeholders and the public to assess a tech giant’s behavior in areas such as tax compliance and the speed at which they take down questionable content.
EU commissioner Thierry Breton, who is spearheading the new rules, told FT that some of those