Moles stop growing when they reach a certain size due to normal interactions between cells, despite having cancer-associated gene mutations, says a new study published today in eLife.
The findings in mice could help scientists develop new ways to prevent skin cancer growth that take advantage of the normal mechanisms that control cell growth in the body.
Mutations that activate the protein made by the BRAF gene are believed to contribute to the development of skin cancer. However, recent studies have shown that these mutations do not often cause skin cancer, but instead result in the formation of completely harmless pigmented moles on the skin. In fact, 90% of moles have these cancer-linked mutations but never go on to form tumours. “Exploring why moles stop growing might lead us to a better understanding of what goes wrong in skin cancer,” says lead author Roland Ruiz-Vega, a postdoctoral researcher at
A combination of two substances secreted by the immune system can cure and prevent rotavirus infection, as well as potentially treat other viral infections that target epithelial cells, which cover body surfaces such as skin, blood vessels, organs and the urinary tract, according to researchers in the Institute for Biomedical Sciences at Georgia State University.
Rotavirus, which causes severe, life-threatening diarrhea in young children and moderate gastrointestinal distress in adults, leads to thousands of deaths in children annually, particularly in developing countries where rotavirus vaccines are only moderately effective. Rotavirus is an RNA virus that primarily infects intestinal epithelial cells.
The substances identified in the study, officially known as cytokines, are interleukin 18 (IL-18) and interleukin 22 (IL-22). IL-18 and IL-22 are produced when the body detects a protein in the whip-like appendage of bacteria.
The study, which investigated how these cytokines inhibit rotavirus infection, found when mice were treated
NEW YORK, Oct. 2, 2020 /PRNewswire/ — CEC Elevator Cab Corp. officially announced its latest innovative contribution to the elevator manufacturing business: Sterilyft (https://www.sterilyft.com/). Sterilyft is a completely unique elevator air filtration and sterilization system made in America to fight the current pandemic, and prevent future pathogenic spread. Sterilyft uses the germicidal power of UV-C light to kill pathogens, double MERV 13 filtering and then adding purified air back into the elevator cab space in a closed loop arrangement. CEC Elevator Cab Corp. manufactures Sterilyft in its Bronx-based facility, and has already installed the system in seven different states across the U.S., with plans to fill recent orders across the globe.
“We’re very proud to announce the Sterilyft system. It’s absolutely the latest in pathogenic-fighting technology for the elevator cab space,” said Nick Gretsuk, Executive Vice President at CEC Elevator Cab Corp. “The only way we’re going
My community of Big Bear City, in the mountains east of Los Angeles, had a tense week recently. For a few nerve-racking days, the El Dorado fire, which has burned more than 20,000 acres in and around the San Bernardino National Forest, threatened to move our way.
The fire had seen little movement in the previous days, despite the fact that it was burning in dense forests with many dead trees and downed logs. Weather conditions had been cool and calm. Then things changed, and quickly. The weather shifted to hot, dry and windy. Right away, the El Dorado fire began spreading much more rapidly, toward Big Bear. We were notified to prepare for potential evacuation. Several days later, temperatures cooled again, winds died down and fire activity calmed.
Ship strikes are a leading cause of whale deaths worldwide and kill more than 80 fin, humpback, and blue whales on the U.S. west coast each year. Many of these ships are enormous – waterborne towers that are often unable to detect whales or their spouts.
This has led the National Oceanic and Atmospheric Administration (NOAA) to establish speed reduction programs along both coasts to protect endangered right whales in the Atlantic Ocean (via “Right Whale Slow Zones”) and humpback, gray and blue whales in the Pacific Ocean (through a voluntary speed reduction program). These measures are highly effective at preventing vessels from fatally colliding with whales by 80 – 90 percent, but are not adopted by all maritime ships.
“One of our goals is to provide real-time whale presence data that will help