AB Science announces that results from masitinib study AB07015 in severe asthma have been …

Paris, 13 October 2020, 6pm

Results from masitinib study AB07015 in severe asthma selected for presentation at an American Thoracic Society (ATS) symposium held on 16th October, 2020

AB Science SA (Euronext – FR0010557264 – AB) today announced that results from masitinib study AB07015 in severe asthma have been selected for presentation at an upcoming American Thoracic Society (ATS) symposium.

The ATS Allergy, Immunology, and Inflammation Assembly will host a virtual symposium on October 16, 2020 at 10 am (Eastern Standard Time). This is a chaired virtual meeting during which selected abstracts from the ATS 2020 International Conference (ATS 2020 Virtual) are presented live with questions from moderators and audience.  

Pascal Chanez, Professor of Respiratory Diseases at Aix-Marseille University, France, will present the results of masitinib as a treatment of severe corticosteroid-dependent asthma.

Details for the presentation are as follows:

Session Title:                  Late Breaking Clinical Trials in Airway Diseases
Date

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IMF sees less severe global contraction but trouble in emerging markets

WASHINGTON (Reuters) – Forecasts for the global economy are “somewhat less dire” as rich nations and China have rebounded quicker than expected from coronavirus lockdowns, but the outlook for many emerging markets has worsened, the International Monetary Fund said on Tuesday.

FILE PHOTO: Gita Gopinath, Economic Counsellor and Director of the Research Department at the International Monetary Fund (IMF), speaks during a news conference in Santiago, Chile, July 23, 2019. REUTERS/Rodrigo Garrido/File Photo

The IMF forecast a 2020 global contraction of 4.4% in its latest World Economic Outlook, an improvement over a 5.2% contraction predicted in June, when pandemic-related business closures reached their peak.

The global economy will return to growth of 5.2% in 2021, the IMF said, but the rebound will be slightly weaker than forecast in June, partly due to the extreme difficulties for many emerging markets and a slowdown in the reopening of economies due to the

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IMF sees less severe global contraction but worsening outlook for many emerging markets

WASHINGTON (Reuters) – The International Monetary Fund on Tuesday said forecasts for the global economy were “somewhat less dire” as wealthy countries and China rebounded more quickly than expected from coronavirus lockdowns but warned that the outlook was worsening for many emerging markets.

FILE PHOTO: Gita Gopinath, Economic Counsellor and Director of the Research Department at the International Monetary Fund (IMF), speaks during a news conference in Santiago, Chile, July 23, 2019. REUTERS/Rodrigo Garrido/File Photo

The IMF forecast a 2020 global contraction of 4.4% in its latest World Economic Outlook, an improvement over a 5.2% contraction predicted in June, when business closures reached their peak. It is still the worst economic crisis since the 1930s Great Depression, the Fund said.

The global economy will return to growth of 5.2% in 2021, the IMF said, but the rebound will be slightly weaker than forecast in June, partly due to the extreme

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U.S., UK and other countries warn tech firms that encryption creates ‘severe risks’ to public safety

  • Lawmakers from countries within the Five Eyes intelligence-sharing alliance have urged tech firms to develop backdoors that allows them to access encrypted messages.
  • In an open statement, seven nations said that unbreakable encryption technology “creates severe risks to public safety.”
  • While citizens benefit from additional privacy, law enforcement agencies see end-to-end encryption as a barrier to their investigations.



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LONDON — Lawmakers from countries within the Five Eyes intelligence-sharing alliance have warned tech firms that unbreakable encryption technology “creates severe risks to public safety.”

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Ministers from the U.S., U.K., Canada, Australia and New Zealand published a statement Sunday calling on the tech industry to develop a solution that enabled law enforcement to access tightly encrypted messages.

“We urge industry to address our serious concerns where encryption is applied in a way that wholly precludes any legal access to content,” the statement, which was signed by

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Breakthrough discovery in gene causing severe nerve conditions — ScienceDaily

Researchers have made a breakthrough genetic discovery into the cause of a spectrum of severe neurological conditions.

A research study, led by the Murdoch Children’s Research Institute (MCRI) and gracing the cover of and published in the October edition of Human Mutation, found two new mutations in the KIF1A gene cause rare nerve disorders.

MCRI researcher Dr Simranpreet Kaur said mutations in the KIF1A gene caused ‘traffic jams’ in brain cells, called neurons, triggering a devastating range of progressive brain disorders. KIF1A-Associated Neurological Disorders (KAND) affects about 300 children worldwide.

“KAND symptoms often appear at birth or early childhood, have varying severity and can result in death within five years of life. Because clinical features overlap with other neurological disorders, children can be misdiagnosed or remain undiagnosed for a long period of time,” she said.

“Our study will lead to more diagnoses by expanding the mutation pool further, finding

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Most of Mass. under severe or extreme drought conditions, National Drought Monitor says

Most of Massachusetts is currently under “severe” or “extreme” drought conditions, the National Drought Monitor said Thursday.

An updated map released by the monitor Thursday said southeastern Massachusetts and the Cape and Islands were in the extreme drought category, as was a stretch of the northern part of Middlesex County.

The monitor describes extreme drought as a level that can bring significant crop and pasture losses, as well as “water shortages or restrictions,” according to its website.

Among the Massachusetts communities enacting restrictions Thursday was Cohasset.

Town officials said Thursday in a statement that a drought warning was “currently in effect for all residents,” and that the warning carries “stricter mandatory outdoor water restrictions” than those previously imposed on Sept. 1 due to “abnormally dry conditions.”

The stricter measures that took effect Thursday, the statement said, include a prohibition on using irrigation systems. In addition, officials said, a “handheld hose

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The ancient Neanderthal hand in severe COVID-19 — ScienceDaily

Since first appearing in late 2019, the novel virus, SARS-CoV-2, has had a range of impacts on those it infects. Some people become severely ill with COVID-19, the disease caused by the virus, and require hospitalization, whereas others have mild symptoms or are even asymptomatic.

There are several factors that influence a person’s susceptibility to having a severe reaction, such as their age and the existence of other medical conditions. But one’s genetics also plays a role, and, over the last few months, research by the COVID-19 Host Genetics Initiative has shown that genetic variants in one region on chromosome 3 impose a larger risk that their carriers will develop a severe form of the disease.

Now, a new study, published in Nature, has revealed that this genetic region is almost identical to that of a 50,000-year old Neanderthal from southern Europe. Further analysis has shown that, through interbreeding,

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Strong activation of anti-bacterial T cells linked to severe COVID-19 — ScienceDaily

A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal Science Immunology. The findings contribute to increased understanding about how our immune system responds against COVID-19 infection.

“To find potential treatments against COVID-19, it is important to understand in detail how our immune system reacts and, in some cases, perhaps contribute to worsening the disease,” says Johan Sandberg, professor at the Department of Medicine, Huddinge, at Karolinska Institutet and the study’s corresponding author.

T cells are a type of white blood cells that are specialized in recognizing infected cells, and are an essential part of the immune system. About 1 to 5 percent of T cells in the blood of healthy people consist of so-called MAIT cells (mucosa-associated invariant T cells), which

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Severe marine heat waves linked to human-caused warming

Unusually hot zones in the ocean likely will become longer, more frequent.

This is an Inside Science story.

The scientists, led by postdoctoral researcher Charlotte Laufkötter at the University of Bern in Switzerland, focused on seven well-documented marine heat waves from the past decade. For each hot spell, they calculated the relative probabilities that a similar event could have occurred with and without human influence. They found that human activities such as greenhouse gas emissions made the heat waves much more likely

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Driven by climate, more frequent, severe wildfires in Cascade Range reshape forests — ScienceDaily

In recent years — and 2020 is no exception — parts of the Pacific Northwest that are typically too wet to burn are experiencing more frequent, severe and larger wildfires due to changes in climate. New research from Portland State University found that while the increased wildfire activity is causing widespread changes in the structure and composition of these mid-to-high elevation forests, the new landscapes are also likely more resilient to projected upward trends in future fire activity and climate conditions.

The study, led by PSU graduate student Sebastian Busby, examined temperate forests that burned expansively, severely and repeatedly between 2003 and 2015 in the central Cascade Range of Oregon and Washington. On Mt. Adams, these wildfires included the 2008 Cold Springs, 2012 Cascade Creek and 2015 Cougar Creek fires. On Mt. Jefferson, the wildfires included the 2003 Booth and Bear Butte Complex, 2007 Warm Springs Area Lightning Complex and

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