REDWOOD CITY, Calif., Oct. 7, 2020 /PRNewswire/ — Synthego, the genome engineering company, today announced the design of new foundational technology for standardized precision and control of CRISPR-based gene editing inside cells using light. Described in Nature Communications, Synthego researchers developed a new class of guide molecules, CRISPRoff™, a synthetic sgRNA that fragments in response to light, enabling precise temporal and spatial control of double-strand breaks created during gene editing. The publication follows Synthego’s extension of the collaboration with the National Institute of Standards and Technology (NIST) Genome Editing Consortium to further standards for precise and reproducible gene editing in therapeutic development.
“CRISPRoff and our NIST Consortium collaboration highlight our deep commitment and ability to create cutting-edge CRISPR platforms to standardize predictable gene editing across a variety of disease areas, helping drive the industry forward,” said Robert Deans, Ph.D., chief scientific officer of Synthego. “The ability to